Durataz 4.5 gm Injection — Overview, Uses, Dosage & Price

What is Durataz?
Durataz is a combination antibiotic injection. Its active ingredients are:

Piperacillin 4.0 g
Tazobactam 0.5 g

This combination is used to treat serious bacterial infections that may not respond to simpler antibiotics.

When is it used?
Durataz 4.5 gm may be prescribed for infections such as: lung infections (pneumonia), complicated urinary tract infections (UTI), abdominal infections, skin and soft-tissue infections, severe wound/diabetic foot infections, and sepsis (blood infection). 1mg+2MIMS+2

How does it work?
Piperacillin attacks and destroys bacterial cell walls. Meanwhile, Tazobactam inhibits bacterial enzymes (beta-lactamases) that some bacteria produce to resist antibiotics — thereby restoring Piperacillin’s efficacy. PharmEasy+2Genericbucket+2

Dosage & Administration
Durataz 4.5 gm is given as an intravenous (IV) injection — usually in hospital or clinical setting. Commonly, for adults, the dose is: 4.5 gm every 6 to 8 hours, depending on severity of infection, patient’s kidney function, and doctor’s assessment. MIMS+1
(Note: Always follow doctor’s prescription; do not self-administer.)

Price & Approx. Cost / Margin — India (2025)

Source / Store	Approx. Price per Vial of Durataz 4.5 gm
Online pharmacy listing	₹ 165.86 (offer price) PharmEasy
Another source listing	₹ 261–₹ 272 per injection vial 1mg+1
Alternate listing / voucher	₹ 259.33 per injection vial (after discount) PharmAssist

Regulated ceiling price (for generic piperacillin + tazobactam 4 g + 500 mg injection)
According to recent pricing regulation by National Pharmaceutical Pricing Authority (NPPA), the ceiling price for 4 g + 500 mg injection is ₹ 467.30 per pack (dual-chamber bag) — but actual retail price of some brands/generic packs like Durataz is often lower. Drugs Control Department+1

Profit / Margin Consideration

If a pharmacy buys Durataz (or generic piperacillin–tazobactam) at say ₹ 165–260 per vial (wholesale), and sells at MRP or higher retail (~₹ 260–₹ 470 depending on pack), there is potential margin.
Margin will depend on wholesale cost, sales volume, and regulatory price limit (ceiling price).
Since antibiotic injections are regulated (scheduled formulations), selling above ceiling price plus applicable GST may not be permitted — so pharmacies typically operate within regulated price band. MIMS+2Drugs Control Department+2

Important: Because of regulations by NPPA, the “ceiling price” acts as a limit on what can be charged — selling far above that can be illegal or unethical.

Why Durataz is Important (Pros)

Broad-spectrum: Effective against many types of bacteria, including ones producing resistance enzymes.
Useful for serious and complicated infections — where oral antibiotics may fail.
Often less expensive compared to some high-end branded injections of same composition (depending on generic vs brand).

Risks & Considerations (Cons)

Must be administered via IV — requires hospital/clinic setting; not for self-administration.
Possible side-effects: nausea, vomiting, diarrhea, skin rash, allergic reactions. Severe allergy (rare) may cause breathing difficulty — medical supervision is essential. 1mg+1
Patients with kidney issues need careful dosing adjustment (doctor’s discretion). MIMS
Must complete full course even if symptoms improve — to avoid relapse or resistance.

Sample Blog Content


### Durataz 4.5 gm Injection — Essential Antibiotic for Serious Infections

**What is Durataz?**  
Durataz is an injectable antibiotic containing Piperacillin (4.0 g) and Tazobactam (0.5 g). It is used for treating serious bacterial infections — such as pneumonia, complicated urinary tract infections, skin & soft-tissue infections, abdominal infections, diabetic foot infections, and sepsis.

**How Does It Work?**  
Piperacillin targets and destroys the bacterial cell wall. Many bacteria produce enzymes called beta-lactamases that neutralize such antibiotics. Tazobactam inhibits these enzymes, thus restoring the antibiotic's effectiveness.

**Dosage & Administration**  
- Given intravenously (IV) in hospital/clinic.  
- Adult dose commonly 4.5 gm every 6–8 hours (as per doctor’s advice and severity).  
- Duration depends on type and severity of infection. Use only under medical supervision.

**Price & Availability (India, 2025)**  
Retail vial price of Durataz 4.5 gm varies between ~₹165 to ~₹260 depending on source/discount.  
According to recent regulatory guidelines, the ceiling price for this type of injection (4 g + 500 mg strength) is ₹467.30 per pack — actual market price is often lower.  

**Why Use Durataz?**  
- Broad-spectrum antibiotic effective against many bacteria.  
- Useful for serious infections where simpler antibiotics fail.  
- Generic version often provides cost-effective treatment compared to high-end branded injectables.  

**Risks & Precautions**  
- IV use only, under medical supervision.  
- Possible side-effects: nausea, vomiting, diarrhea, rash, allergic reactions (rare but serious possible).  
- Patients with kidney problems must be carefully dosed.  
- Complete full course even if symptoms improve.  

**Note:** Always use Durataz only on prescription. Self-administration is dangerous.